20170412-lava-VISUAL-edited

NEXT-GENERATION T-CELL ENGAGERS

ABOUT US

Lava Therapeutics B.V. is a biotech company that develops proprietary Vγ9Vδ2 T-cell engagers based on the scientific advancements of the VU University Medical Center in Amsterdam.

The objective is to develop cost-effective next-generation immune oncology biopharmaceuticals delivering the primary targeted treatment in combination with immune recruiting and activating functionality.

Ton Adang

PhD, CDO
Ton Adang worked at several biotech companies and at Merck/MSD, Schering-Plough and Organon in research and development positions with increasing responsibilities.
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Hans van der Vliet

MD, PhD, CSO/CMO
Hans van der Vliet is a medical oncologist and associate professor at the department of medical oncology of the VU University medical center-Cancer Center Amsterdam.
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Erik van den Berg

MSc, MBA, Advisor

Erik has over twenty years experience in the pharmaceutical industry. He is the CEO of AM-Pharma and board member of several (bio)tech companies.

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SCIENCE

A recent meta-analysis of expression signatures from ~18,000 human tumors with overall survival outcomes demonstrated that intra-tumoral γδ T-cell signatures constituted the most favorable cancer-wide prognostic cell population across 39 malignancies [1].

Moreover, activation of residing Vγ9Vδ2 T-cells or adoptive transfer of Vγ9Vδ2 T-cells can result in clinically significant tumor responses [2-5].

LAVA’s Vγ9Vδ2 T-cell engagers uniformly and specifically bind to the conserved (monomorphic) T-cell receptor of Vγ9Vδ2 T-cells that constitute a unique proinflammatory immune effector cell population, providing a consistent response and avoid generalized T cell activation known to induce side effects and to reduce anti-tumor effects. The cells exhibit potent cytotoxicity and interferon-γ secretion and HLA-unrestricted tumor cell killing and have antigen-presenting capabilities for αβ-T cells promoting the development of  adaptive immune responses.

Proof of principle has been established by in vitro and in vivo studies in which Vγ9Vδ2 T-cell engagers demonstrate potent tumor lysis independent of signaling escape mechanisms.

The company is working on several lead bispecific Vγ9Vδ2 T-cell engager candidates progressing towards the clinic.

PARTNERING

Lava develops proprietary bispecific Vγ9Vδ2 T-cell engagers for selected tumor targets. Pharmaceutical companies with an interest to use Lava’s Vγ9Vδ2 T-cell engagers for own tumor targets or with an interest in Lava’s lead projects should contact Lava via info@lavatherapeutics.com.

Collaborations are a key part of our business strategy and we are actively seeking new partnerships with companies whom are interested in licensing our products and proprietary technologies.

NEWS

Lava Therapeutics licenses leading edge Vγ9Vδ2 T-cell immune oncology assets

INVESTORS

CAREERS

Thank you for your interest in a career at Lava Therapeutics. We currently have no vacancies available, but always feel free to contact us to enquire whether (and which) positions might become available in the near future. We are continuously looking for talented people to help us develop bispecific Vγ9Vδ2 T-cell engagers to fight cancer.

CONTACT US

+31 8 506 573 44

Onderwijsboulevard 225
5223 DE, ’s-Hertogenbosch
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